Perhaps it was the moment Kate Moss stepped on to the catwalk wearing the student collection of a young Stella McCartney in 1995.
Maybe it was when Grace Jones grooved on a limousine roof, or when Katharine Hamnett got one over on Margaret Thatcher.
London Fashion Week celebrates its 25th anniversary next month, and to commemorate the occasion Vogue has compiled a list of the 25 most important events in its history.
The seminal moments include Hamnett winning the first Designer of the Year award in 1984.
She made a political statement, wearing a T-shirt emblazoned with "58 per cent don't want Pershing" to a Downing Street reception.
Mrs Thatcher, who supported America's use of the Pershing II missiles, maintained a poker face when they met.
London Fashion Week launched the careers of top designers and models.
A little-known John Galliano was British Designer of the Year in 1987, and Alexander McQueen's debut made headlines in 1992 for its low-cut "bumster" trousers. Sophie Dahl made her size-14 modelling debut there in 1997.
The event has also attracted some of the biggest names in music.
Prince performed at Matthew Williamson's show in 2007, while in 2000 Grace Jones danced on a limousine for Philip Treacy's show.
Post Spice Girls, Victoria Beckham's first foray into high fashion came in February 2000 when she modelled, nervously, a pair of green hotpants for Maria Grachvogel.
Fashion week is famous for experimental designs - Hussein Chalayan's "table dress" from his autumn/winter 2001-02 show being an extreme example.
There are also more solemn moments. In 2002 London agreed to swap dates with New York, which felt it was inappropriate for its event to fall on the first anniversary of 9/11.
